The antibody response to tumor inoculation; improved methods of antibody detection.

The literature on the immunological aspects of tumor transplantation has been well reviewed by Hauschka (9), so it is necessary only to point out certain technical problems that form the basis for the present communication. The most striking recent advances in our knowledge of the genetics of tumor transplanta tion have been due to the work of Snell and his colleagues on the H-2 locus (13) and the idejtification of two further histocompatibility loci (12). The H-2 locus received its title from an A strain antigen called antigen II by the senior author (3, 4), which Gorer, Lyman, and Snell (7) showed to be linked to the locus for "fused" (an anomaly of the tail). This antigen (more correctly "antigens,"